DEPOPULATE /diːˈpɒpjəleɪt/ Scrabble 15 Words With Friends 19 Scrabble letter values: D2E1P3O1P3U1L1A1T1E1 = 15 Definition verb reduce in population. — synonyms: desolate Examples “The epidemic depopulated the countryside” See all 291 words you can make from DEPOPULATE → 10-letter words Words starting with D Words ending with E ← Unscramble different letters