DEPOPULATION /diːˌpɒpjəˈleɪʃən/ Scrabble 17 Words With Friends 22 Scrabble letter values: D2E1P3O1P3U1L1A1T1I1O1N1 = 17 Definition noun the condition of having reduced numbers of inhabitants (or no inhabitants at all). See all 811 words you can make from DEPOPULATION → 12-letter words Words starting with D Words ending with N ← Unscramble different letters