DESPERATION /ˌdɛspəˈɹeɪʃən/ Scrabble 14 Words With Friends 16 Definition noun a state in which all hope is lost or absent. — synonyms: despair noun desperate recklessness. See all 1914 words you can make from DESPERATION → 11-letter words Words starting with D Words ending with N ← Unscramble different letters