DOWNER /ˈdaʊnə/ ► audio Scrabble 10 Words With Friends 11 Definition noun a drug that reduces excitability and calms a person. — synonyms: sedative, sedative_drug, depressant Examples “Normally those pills give me a boost, but last night they gave me a downer.” Anagrams of DOWNER wonder See all 70 words you can make from DOWNER → 6-letter words Words starting with D Words ending with R ← Unscramble different letters