ISTHMUS /ˈɪs.məs/ ► audio Scrabble 12 Words With Friends 13 Definition noun a relatively narrow strip of land (with water on both sides) connecting two larger land areas. noun a cord-like tissue connecting two larger parts of an anatomical structure. — synonyms: band See all 74 words you can make from ISTHMUS → 7-letter words Words starting with I Words ending with S ← Unscramble different letters