POX /pɑks/ Scrabble 12 Words With Friends 13 Definition noun a common venereal disease caused by the treponema pallidum spirochete. — synonyms: syphilis, syph, lues_venerea, lues noun a contagious disease characterized by purulent skin eruptions that may leave pock marks. See all 3 words you can make from POX → 3-letter words Words starting with P Words ending with X ← Unscramble different letters