QUINTESSENCE /kwɪn.ˈtɛs.əns/ Scrabble 23 Words With Friends 27 Definition noun the fifth and highest element after air and earth and fire and water. — synonyms: ether noun the purest and most concentrated essence of something. noun the most typical example or representative of a type. See all 283 words you can make from QUINTESSENCE → 12-letter words Words starting with Q Words ending with E ← Unscramble different letters