SIMPLEST /ˈsɪmpləst/ Scrabble 12 Words With Friends 15 Definition SIMPLEST is the superlative of SIMPLE. noun SIMPLE: any herbaceous plant having medicinal properties. Anagrams of SIMPLEST misspelt See all 205 words you can make from SIMPLEST → 8-letter words Words starting with S Words ending with T ← Unscramble different letters