VACUOLE /ˈvækjʊˌəʊl/ Scrabble 12 Words With Friends 16 Scrabble letter values: V4A1C3U1O1L1E1 = 12 Definition noun a tiny cavity filled with fluid in the cytoplasm of a cell. See all 63 words you can make from VACUOLE → 7-letter words Words starting with V Words ending with E ← Unscramble different letters