VICISSITUDE [vaɪˈsɪs.ɨˌt(j)u(ː)d] ► audio Scrabble 17 Words With Friends 20 Definition noun a variation in circumstances or fortune at different times in your life or in the development of something. noun mutability in life or nature (especially successive alternation from one condition to another). See all 212 words you can make from VICISSITUDE → 11-letter words Words starting with V Words ending with E ← Unscramble different letters